Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age
نویسندگان
چکیده
منابع مشابه
Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age.
BACKGROUND Early-life immune deviation is suspected in the inception of atopic disease. OBJECTIVE To investigate the association between cord blood chemokines and the subsequent development of atopic biomarkers and clinical end-points during the first 6 years of life. METHODS The Th1-associated chemokines CXCL10 and CXCL11 and the Th2-associated chemokines CCL17 and CCL22 were assessed in c...
متن کاملPrediction of elevated cord blood IgE levels by maternal IgE levels, and the neonate's gender and gestational age.
BACKGROUND Elevation of cord blood immunoglobulin E (IgE) is used to predict childhood atopy. In an effort to catch such problems at an earlier time, we sought to identify the impact of parental atopy as well as gestational age, the baby's gender, and the season of delivery on cord blood IgE levels. METHODS The allergic history of parents was collected during pregnancy. Blood samples from par...
متن کاملTotal and antigen-specific Ige levels in umbilical cord blood
The present study was conducted to learn whether the perinatal and environmental factors could influence the total and antigen-specific IgE levels in umbilical cord blood. Retrospective data were obtained from 173 mother-infant pairs. Total and specific (for children's food, wheat/grass and house dust mite-HDM) cord blood IgE levels were determined using the immunoassay test. The total cord blo...
متن کاملHigh cord blood CCL22/CXCL10 chemokine ratios precede allergic sensitization in early childhood
Atopic diseases are known to be characterized by a T helper (Th) 2-skewed immunity; however, there are few studies addressing the Th1/Th2 immunity at birth related to the development of atopic diseases in early childhood. We investigated 186 children followed up regularly at the clinic for 4 years in a birth cohort study. The Th1-associated CXC chemokine ligand (CXCL)-10, CXCL11, and the Th2-as...
متن کاملCord blood cytokines and chemokines and development of allergic disease.
Exposure to ubiquitous allergens early in life, even before birth, may influence the incidence of allergic diseases later in life. During pregnancy, the fetomaternal interface is surrounded by high levels of T-helper (Th)2-like cytokines, possibly favouring the development of Th2-like immune responses in the offspring. The aim of this study was to evaluate the relation between cord blood (CB) I...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical & Experimental Allergy
سال: 2012
ISSN: 0954-7894
DOI: 10.1111/j.1365-2222.2012.04048.x